منابع مشابه
Liver Glucokinase and Lipid Metabolism
Control of energy metabolism is crucial for optimal functioning of organs and tissues. Amongst all nutrients, glucose is the principal energy source for most cells and, therefore, minimum blood glucose levels must be guaranteed. Alterations in glycaemia can lead to hyperglycaemic states (producing protein glycosylation and toxicity in glucose-sensitive cells) or hypoglycaemic states (that can a...
متن کاملGlucokinase of Rabbit Liver PURIFICATION AND PROPERTIES* Josti SALAS,~ MARGARITA SALAS,$ ELADIO VIRUELA,J AND ALBERTO SOLS
It has been recently shown that in rat liver there are two enzymes which phosphorylate glucose to glucose 6-phosphate. One of them is a hexokinase with a great affinity for glucose and, like those of other animal tissues it is inhibited by glucose 6phosphate; the other one, named glucokinase, has a low affinity for glucose, is not inhibited by glucose 6phosphate, and appears to be responsible f...
متن کاملInhibition by catecholamines of the induction of rat liver glucokinase.
Epinephrine, norepinephrine, and isoproterenol prevent the induction of rat liver glucokinase (EC 2.7.1.2) produced by the administration of glucose to animals with low levels of the enzyme. The low levels of glucokinase were obtained by feeding the animals a carbohydrate-free diet for 6 days. When epinepbrine was given 4 hours after the administration of carbohydrate there was only a slight in...
متن کاملIsolated mouse liver mitochondria are devoid of glucokinase.
Glucokinase is a hexokinase isoform with low affinity for glucose that has previously been identified as a cytosolic enzyme. A recent report claims that glucokinase physically associates with liver mitochondria to form a multi-protein complex that may be physiologically important in apoptotic signaling [N.N. Danial, C.F. Gramm, L. Scorrano, C.Y. Zhang, S. Krauss, A.M. Ranger, S.R. Datta, M.E. G...
متن کاملGlucokinase and molecular aspects of liver glycogen metabolism.
Conversion of glucose into glycogen is a major pathway that contributes to the removal of glucose from the portal vein by the liver in the postprandial state. It is regulated in part by the increase in blood-glucose concentration in the portal vein, which activates glucokinase, the first enzyme in the pathway, causing an increase in the concentration of glucose 6-P (glucose 6-phosphate), which ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97530-7